Bicer 2006.

Methods	RCT, 3 parallel groups
Participants	Number: 120 men (n = 74) and women (n = 46) Country: Turkey Surgery: elective abdominal and orthopaedic, lasting 1 to 3 hours Age: 18 to 50 years ASA: I to II Other inclusion criteria: none stated Exclusion criteria: BMI > 27 kg/m2; fever; use of vasoactive, antidepressant or analgesic drugs; history of cardiovascular, respiratory, endocrine or neurological disease; pregnancy
Interventions	Dexmedetomidine 1 µg/kg intravenously at the time of wound closure (n = 40) vs Meperidine 0.5 µg/kg intravenously at the time of wound closure (n = 40) vs Saline 0,9% at the time of wound closure (n = 40)
Outcomes	Postoperative sedation, grade 1 to 6 Postoperative pain, grade 0 to 4 Postoperative nausea and vomiting Postoperative analgesic requirements (not specifying type of analgesia) Postoperative antiemetic requirements
Notes	Study authors contacted for type of abdominal surgery and individual participant data, and to obtain data on type of rescue analgesia and data on postanaesthetic pain. Study authors sent 1 reply, but not to the above mentioned details. Awaiting new reply