Scheinin 1992.

Methods	RCT, 2 parallel groups
Participants	Number: 24 men (n = 11) and women (n = 13) Country: Finland Surgery: laparotomy, breast surgery, anal surgery, various surgery Age: adults ASA: I Other inclusion criteria: none stated Exclusion criteria: use of any medication, childbearing potential, known allergy
Interventions	Dexmedetomidine 0.6 μg/kg intravenous bolus over 10 minutes before induction of anaesthesia vs Saline, identical volume and timing
Outcomes	Analgesic requirements during the first 2 hours postoperatively
Notes	Study authors contacted to obtain specific data for abdominal surgery, but no reply (study from 1992)