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. 2016 Feb 18;2016(2):CD010358. doi: 10.1002/14651858.CD010358.pub2

Yektas 2011.

Methods RCT, 9 parallel groups
Participants Number: 180 participants (9 × 20)
Country: Turkey
Surgery: inguinal surgery
Age: 20 to 30 years
ASA: I
Other inclusion criteria: spinal anaesthesia
Exclusion criteria: drug abuse, recall of pain at earlier surgery, need for additional sedation at earlier surgery, cerebrospinal fluid could not be obtained after 3 attempts, education level below primary school
Interventions Control group: 15 mg hyperbaric bupivacaine and 0.5 mL physiological serum intrathecally
vs
In the other groups, serum was replaced with the following to a total volume of 3.5 mL:
  • Hyperbaric bupivacaine 2.5 mg


vs
  • Ketamine 12.5 mg


vs
  • Fentanyl 25 µg


vs
  • Sufentanil 2.5 µg


vs
  • Dexmedetomidine 2 µg


vs
  • Neostigmine 250 µg


vs
  • Midazolam 500 µg


vs
  • Droperidole 1.25 mg

Outcomes Intraoperative and postoperative side effects
Time to first pain
Notes Only abstract of conference paper available. Study authors contacted for additional information, awaiting reply

RCT: randomized controlled trial; ASA: American Society of Anesthesiologists Physical Status 1 to 6, where 1 = Healthy person, 2 = Mild systemic disease, 3 = Severe systemic disease, 4 = Severe systemic disease that is a constant threat to life, 5 = A moribund person who is not expected to survive without the operation, 6 = A declared brain‐dead person whose organs are being removed for donor purposes; PCA: patient‐controlled analgesia; PACU: post‐anaesthesia care unit; BMI: body mass index