1.1 Proportion of children whose hearing is normal (very short‐term, < 6 weeks) |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
1.2 Proportion of children whose hearing is normal (short‐term, > 6 weeks to ≤ 3 months) |
1 |
94 |
Risk Ratio (M‐H, Random, 95% CI) |
2.67 [1.73, 4.12] |
1.3 Hearing threshold (very short‐term, < 6 weeks) |
1 |
45 |
Mean Difference (IV, Random, 95% CI) |
‐5.00 [‐10.10, 0.10] |
1.4 Hearing threshold (short‐term, > 6 weeks to ≤ 3 months) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
1.4.1 0.5 kHz |
2 |
113 |
Mean Difference (IV, Random, 95% CI) |
‐9.13 [‐15.14, ‐3.13] |
1.4.2 1.0 kHz |
2 |
113 |
Mean Difference (IV, Random, 95% CI) |
‐10.34 [‐17.85, ‐2.83] |
1.4.3 2.0 kHz |
2 |
113 |
Mean Difference (IV, Random, 95% CI) |
‐9.04 [‐14.84, ‐3.25] |
1.4.4 4.0 kHz |
2 |
113 |
Mean Difference (IV, Random, 95% CI) |
‐12.88 [‐17.01, ‐8.75] |
1.5 Disease‐specific quality of life (short‐term, > 6 weeks to ≤ 3 months) |
1 |
247 |
Mean Difference (IV, Random, 95% CI) |
‐0.42 [‐0.62, ‐0.22] |
1.6 Adverse events ‐ pain and distress caused by the procedure (otalgia) |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
1.6.1 Otalgia |
1 |
320 |
Risk Ratio (M‐H, Random, 95% CI) |
3.50 [0.74, 16.59] |
1.7 Persistence of OME (very short‐term, < 6 weeks) |
7 |
688 |
Risk Ratio (M‐H, Random, 95% CI) |
0.86 [0.72, 1.04] |
1.7.1 Per ear data |
6 |
670 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.69, 1.04] |
1.7.2 Per child data |
1 |
18 |
Risk Ratio (M‐H, Random, 95% CI) |
1.00 [0.72, 1.39] |
1.8 Persistence of OME (short‐term, > 6 weeks to ≤ 3 months) |
4 |
483 |
Risk Ratio (M‐H, Random, 95% CI) |
0.88 [0.80, 0.97] |
1.8.1 Per ear data |
3 |
466 |
Risk Ratio (M‐H, Random, 95% CI) |
0.87 [0.79, 0.96] |
1.8.2 Per child data |
1 |
17 |
Risk Ratio (M‐H, Random, 95% CI) |
1.12 [0.61, 2.07] |
1.9 Episodes of acute otitis media (short‐term, > 6 weeks to ≤ 3 months) |
2 |
403 |
Risk Ratio (M‐H, Random, 95% CI) |
0.82 [0.49, 1.36] |
1.10 Sensitivity analysis: Proportion of children whose hearing is normal (very short‐term, < 6 weeks). Per ear data (ICC of 1, complete correlation between ears) |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
1.11 Sensitivity analysis: Proportion of children whose hearing is normal (very short‐term, < 6 weeks). Per ear data (ICC of 0, no correlation between ears) |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
1.12 Sensitivity analysis: Hearing threshold (short‐term, > 6 weeks to ≤ 3 months). Right ear data |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
1.12.1 0.5 kHz |
2 |
117 |
Mean Difference (IV, Random, 95% CI) |
‐9.13 [‐15.35, ‐2.92] |
1.12.2 1.0 kHz |
2 |
117 |
Mean Difference (IV, Random, 95% CI) |
‐10.91 [‐20.07, ‐1.76] |
1.12.3 2.0 kHz |
2 |
117 |
Mean Difference (IV, Random, 95% CI) |
‐9.59 [‐17.74, ‐1.44] |
1.12.4 4.0 kHz |
2 |
117 |
Mean Difference (IV, Random, 95% CI) |
‐13.37 [‐20.66, ‐6.08] |
1.13 Sensitivity analysis: Hearing threshold (short‐term, > 6 weeks to ≤ 3 months). Left ear data |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
1.13.1 0.5 kHz |
2 |
115 |
Mean Difference (IV, Random, 95% CI) |
‐8.97 [‐14.88, ‐3.06] |
1.13.2 1.0 kHz |
2 |
115 |
Mean Difference (IV, Random, 95% CI) |
‐9.64 [‐15.50, ‐3.78] |
1.13.3 2.0 kHz |
2 |
115 |
Mean Difference (IV, Random, 95% CI) |
‐8.06 [‐12.16, ‐3.97] |
1.13.4 4.0 kHz |
2 |
115 |
Mean Difference (IV, Random, 95% CI) |
‐10.92 [‐15.42, ‐6.41] |
1.14 Sensitivity analysis: Persistence of OME (very short‐term, < 6 weeks). Per ear data (ICC of 0) |
6 |
862 |
Risk Ratio (M‐H, Random, 95% CI) |
0.84 [0.68, 1.04] |
1.15 Sensitivity analysis: Persistence of OME (very short‐term, < 6 weeks). Per ear data (ICC of 1) |
6 |
551 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.70, 1.03] |
1.16 Sensitivity analysis: Persistence of OME (very short‐term, < 6 weeks). Per child data, where available |
7 |
621 |
Risk Ratio (M‐H, Random, 95% CI) |
0.84 [0.68, 1.04] |
1.16.1 Per ear data, adjusted for correlation for those with bilateral disease |
4 |
300 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.55, 1.12] |
1.16.2 Per child data: persistence in any affected ear |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
1.05 [0.88, 1.25] |
1.16.3 Per child data: persistence in all affected ears |
2 |
281 |
Risk Ratio (M‐H, Random, 95% CI) |
0.82 [0.68, 1.00] |
1.17 Sensitivity analysis: Persistence of OME (short‐term, > 6 weeks to ≤ 3 months). Per ear data (ICC of 0) |
4 |
617 |
Risk Ratio (M‐H, Random, 95% CI) |
0.89 [0.82, 0.97] |
1.17.1 Per ear data |
3 |
600 |
Risk Ratio (M‐H, Random, 95% CI) |
0.89 [0.82, 0.97] |
1.17.2 Per child data |
1 |
17 |
Risk Ratio (M‐H, Random, 95% CI) |
1.12 [0.61, 2.07] |
1.18 Sensitivity analysis: Persistence of OME (short‐term, > 6 weeks to ≤ 3 months). Per ear data (ICC of 1) |
4 |
402 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.81, 1.00] |
1.18.1 Per ear data |
3 |
385 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.80, 1.00] |
1.18.2 Per child data |
1 |
17 |
Risk Ratio (M‐H, Random, 95% CI) |
1.12 [0.61, 2.07] |
1.19 Sensitivity analysis: Persistence of OME (short‐term, > 6 weeks to ≤ 3 months). Per child data, where available |
4 |
441 |
Risk Ratio (M‐H, Random, 95% CI) |
0.86 [0.78, 0.96] |
1.19.1 Per ear data |
2 |
179 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.68, 1.06] |
1.19.2 Per child data |
2 |
262 |
Risk Ratio (M‐H, Random, 95% CI) |
0.82 [0.66, 1.02] |