Table 4.
Univariate and multivariate analysis of factors related to the RFS
| Variables | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | p value | HR | (95% CI) | p value | |
| Sex (male) | 1.231 | 0.531–1.827 | 0.690 | |||
| Age (≥65 years) | 0.934 | 0.274–3.182 | 0.914 | |||
| ECOG-PS (1) | 1.773 | 0.520–6.047 | 0.360 | |||
| Hepatitis B infection (positive) | 1.198 | 0.278–5.154 | 0.809 | |||
| WBC count (≥4 × 109/L) | 0.213 | 0.070–0.647 | 0.006 | 0.029 | 0.006–0.136 | <0.001 |
| Hemoglobin level (≥100 g/L) | 0.167 | 0.038–0.745 | 0.019 | 0.060 | 0.011–0.330 | 0.001 |
| PLT count (≥100 × 109/L) | 0.733 | 0.169–3.175 | 0.678 | |||
| Total bilirubin level (≥34 µmol/L) | 1.173 | 0.155–8.864 | 0.877 | |||
| Albumin level (≥35 g/L) | 0.692 | 0.203–2.362 | 0.556 | |||
| ALT level (≥40 IU/L) | 1.162 | 0.492–2.743 | 0.732 | |||
| AST level (≥40 IU/L) | 1.272 | 0.535–3.023 | 0.587 | |||
| Pre-treatment AFP level (≥400 ng/mL) | 1.551 | 0.641–3.754 | 0.330 | |||
| Pre-treatment PIVKA-II (≥400 mAU/mL) | 3.056 | 0.707–13.203 | 0.135 | |||
| Tumor number (single) | 0.330 | 0.110–0.992 | 0.048 | 0.140 | 0.041–0.483 | 0.002 |
| Maximum tumor size (≥10 cm) | 0.710 | 0.301–1.674 | 0.434 | |||
| Macrovascular invasion (positive) | 0.520 | 0.218–1.242 | 0.141 | |||
| Surgical type (laparoscopic) | 0.942 | 0.275–3.223 | 0.924 | |||
| Major hepatectomy (yes) | 0.766 | 0.308–1.904 | 0.567 | |||
| Operative time (≥180 min) | 1.173 | 0.449–3.063 | 0.745 | |||
| Blood loss (≥500 mL) | 0.938 | 0.386–2.279 | 0.887 | |||
| Blood transfusion (yes) | 0.918 | 0.370–2.280 | 0.854 | |||
| Clavien-Dindo classification (IIIb–V) | 6.723 | 1.891–23.901 | 0.003 | 14.535 | 3.210–65.824 | 0.001 |
| Pathological reaction (PCR) | 0.333 | 0.121–0.915 | 0.033 | 0.113 | 0.031–0.409 | 0.001 |
| Microvascular invasion (M0) | 0.629 | 0.253–1.564 | 0.318 | |||
RFS, recurrence-free survival; HR, hazard ratio; CI, confidence interval; ECOG-PS, Eastern Cooperative Oncology Group performance status; WBC, white blood cells; PLT, platelet; ALT, alanine aminotransferase; AST, aspartate transaminase; AFP, alpha fetoprotein; PIVKA-II, protein induced by vitamin K absence-II; PCR, pathological complete response; bold, p < 0.05.