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. 2023 Sep 26;22:160. doi: 10.1186/s12944-023-01922-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Ceramide distribution at different time points. Boxplots of ceramides before and after liraglutide and placebo in (A) LirAlbu12 and (B) LiraFlame26. Line graphs of C16 Cer amount per week over the two trials, modeled as linear mixed models: Ceramide ~ Treatment + Time + Treatment:Time + (1|Participant ID), for (C) LirAlbu12 and (D) LiraFlame26. The ceramide amount was measured as the ratio of ceramide intensity divided by the intensity of pure standard (peak area of ceramide / peak area ceramide standard)