Table 4.

Change in body weight following liraglutide does not mediate change in ceramide levels

	LirAlbu12				LiraFlame26
	Total effect estimate	Total effect P-value	ACME estimate	ACME P-value	Total effect estimate	Total effect P-value	ACME estimate	ACME P-value
C16 Cer	0.025 (-0.03;0.079)	0.372	-0.004 (-0.032;0.021)	0.718	2.634*10–4 (1.954*10–5;5.004*10–4)	0.044	7.641*10–6 (-1.421*10–4;1.796*10–4)	0.908
C18 Cer	0.024 (-0.038;0.088)	0.492	0.003 (-0.028;0.034)	0.758	5.527*10–4 (-1.182*10–4;1.259*10–3)	0.102	4.530*10–5 (-3.698*10–4;4.983*10–4)	0.798
C20 Cer	0.037 (-0.053;0.141)	0.45	0.002 (-0.048;0.047)	0.912	-2.777*10–5 (-7.603*10–5;2.105*10–5)	0.314	2.285*10–5 (-1.929*10–6;5.199*10–5)	0.076
C22 Cer	0.281 (-0.21;0.775)	0.262	0.031 (-0.187;0.241)	0.724	1.432*10–4 (-1.988*10–4;4.755*10–4)	0.37	2.973*10–5 (-1.230*10–4;2.119*10–4)	0.788
C24 Cer	1.272 (-0.762;3.59)	0.238	-0.238 (-1.312;0.687)	0.716	2.703*10–2 (-9.487*10–3;6.170*10–2)	0.168	-1.562*10–3 (-2.448*10–2;1.971*10–2)	0.88
C24:1 Cer	-0.025 (-0.687;0.642)	0.958	0.074 (-0.205;0.403)	0.616	1.178*10–2 (-2.336*10–3;2.387*10–2)	0.094	-9.104*10–4 (-8.647*10–3;6.183*10–3)	0.85

Mediation effect was assessed by linear regression models with and without adjustment for the tested confounder the effect and significance were estimated by bootstrapping 1000 times using the mediator package in R

ACME Average casual mediation effect