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. 2023 Sep 26;20:215. doi: 10.1186/s12974-023-02900-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Immature, transitional and regulatory B cells are the first B cells to repopulate after SID and EID. A UMAP plot displays pre-gated CD19 + cells from the blood of CG, SID and EID patients. Colours correspond to PARC-guided clustering. B Percentage of each annotated B cell population out of the total CD45⁺ cells from CG, SID and EID patients. Each data point corresponds to each individual, columns and error bars show mean ± SEM. P-values indicate the statistical differences after a GLM model with age, sex and type of MS as covariates. C Proportional stacked bar graph showing the percentage of each annotated B cell cluster out of the CD19⁺ cells from CG, SID and EID patients. D Heatmap indicates the median scaled intensity of the corresponding markers across B cell subpopulations. The size of the circles (right) represents the value of the p-value and the colour represents the direction of change between the different experimental groups. *adjusted p-value < 0.05, **adjusted p-value < 0.01, ***adjusted p-value < 0.001, ****adjusted p-value < 0.0001. GLM multivariate general linear model, CG control group, SID standard interval dosing, EID extended interval dosing