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. 2023 Sep 26;23:215. doi: 10.1186/s12935-023-03076-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Functional enrichment analysis in TARGET cohort. A A circle graph showing the results of GO and KEGG enrichment analysis. Red nodes: Up-regulated in high expression of DIO3OS groups; Blue nodes: Down-regulated in high expression of DIO3OS groups. The blue or red color of the Z-score represents the activated or suppressed pathways in functional enrichment analysis. Red: Activated pathway; Blue: Suppressed pathway. B A chord plot showing the results of GO and KEGG enrichment analysis. The blue or red color of the LogFC represents gene expression between samples. Red: Up-regulated; Blue: Down-regulated. C A function enrichment network. Red nodes: genes; Blue Nodes: functional terms. D A bubble plot of GSEA enrichment analysis in TARGET cohort. p < 0.05. E TGF-β signaling pathway was significant enrichment using GSEA enrichment analysis in TARGET cohort