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. 2023 Sep 26;42:249. doi: 10.1186/s13046-023-02821-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — IMPDH2 overexpression relieved the angiogenesis inhibition caused by TMTC3 knockdown. (A) The overexpression efficiency of IMPDH2 in TMTC3 knockdown cells. (B) Representative micrographs of the HUVECs tube formation treated with indicated condition medium (left). Quantification of the capillary length and number of branches (right). (C) The migration ability of HUVECs was measured by transwell assay as described in Materials and Methods. The number of migrated cells were counted by Image J software. (D) Representative images of the blood vessels formed in the CAM assay, after incubation with conditioned medium from the indicated cells. The results are summarized in the graphs as vessel density. (E) Representative IHC images for IMPDH2 and TMTC3 in ESCC tissue array. F and G. IHC staining score for IMPDH2 (F) and TMTC3 (G). H. Correlation of IMPDH2 IHC score and TMTC3 IHC score. All data are expressed as the mean ± SD. *, p < 0.05; **, p < 0.01; ***, p < 0.001. n = 3