Figure 6.

Illustration of the feedback control algorithm. Microbubble infusion was started 15 seconds before FUS sonication and lasted until the end of FUS sonication. During FUS sonication with microbubble infusion, cavitation was monitored by PCD in real-time. The baseline stable cavitation level for each mouse was defined using 10 repeated PCD measurements acquired during dummy FUS sonication. Once target cavitation level was defined relative to baseline stable cavitation level, FUS sonication was performed with the feedback control algorithm in a two-phase process: the pressure ramping-up phase to reach target cavitation level and maintaining phase to keep stable cavitation level within the target range.