Table 1.
Select AVPs with activity against different viruses. Multiple AVPs display high antiviral activity against various viral pathogens. Antiviral and cytotoxic activity values listed here and in our database were either directly stated or inferred from dose-response curves in the sources. Abbreviations: MeV: measles virus; pseudo-EBOV: recombinant vesicular stomatitis virus expressing EBOV-GP.
| AVP | Virus | Antiviral activity (μM) | Cytotoxic activity (μM) | Reference |
|---|---|---|---|---|
| Siamycin I | HIV | 0.08 (ED50) | 150 (TC50) | [53] |
| Polyphemusin II (T22) | HIV | 0.0026 (EC50) | 17.8 (CC50) | [51] |
| Tachyplesin II (T11) | HIV | 0.151 (EC50) | 16.86 (CC50) | [101] |
| Tachyplesin II (T15) | HIV | 0.0375 (EC50) | 22.85 (CC50) | [101] |
| P9 | IAV(H1N1) | 0.36 (IC50) | 113.88 (TC50) | [81] |
| Mucroporin M1 | IAV (H5N1) | 1.03 (EC50) | 41.03 (CC50) | [83] |
| Urumin | IAV (H1N1) | 3.8 (IC50) | 2,450 (TD50) | [86] |
| HNP-1 | IAV | 0.58 (IC50) | N/A | [76] |
| P9 | MERS-CoV | 1.5 (IC50) | 113.88 (TC50) | [81] |
| P9R | SARS-CoV-2 | 0.26 (IC50) | 87.9 (CC50) | [82] |
| Latarcin 1 | DENV | 8.3 (EC50) | 52.51 (CC50) | [102] |
| An1a | ZIKV | 2 (IC50) | >40 (TC50) | [98] |
| GI-20d | Pseudo-EBOV | 0.99 (IC50) | 18.8 (TC50) | [100] |
| 17BIPHE2 | Pseudo-EOV | 0.71 (IC50) | 13.2 (TC50) | [100] |
| Mucroporin M1 | MeV | 3.52 (EC50) | 30.31 (CC50) | [83] |
| Temporin B | HSV-1 | 1.8 (EC50) | 65 (CC50) | [103] |
| Mundticin KS | HSV-2 | 3.5 (EC50) | 3,497 (CC50) | [104] |
| Epinecidin-1 | FMDV | 0.26 (EC50) | 8.35 (CC50) | [105] |