Table 2.
Patient and control demographics: Group characteristics for all individuals combined, for OCD cases, and for controls
| All Individuals | ||
|---|---|---|
| Males | Females | |
| Total N | 97 | 103 |
| N with 5-HTTLPR Genotyped | 75 | 85 |
| N with SNPs Genotyped Across SLC6A4, HTR2A, HTR1B, and HTR2C | 75 | 79 |
| OCD Cases | ||
| Males | Females | |
| Total N | 46 | 51 |
| Mean Age (SD) | 13.2 (3.1) | 13.6 (3.8) |
| Age Range | 6.5- <20.0 | 6.2- <20.0 |
| Mean Total ICV (cc) (SD) | 1684.4 (152.7) | 1534.8 (133.3) |
| Mean PDS Score (SD) | 11.6 (3.4) | 12.3 (5.6) |
| PDS Score Range | 5–17 | 1–19 |
| Mean CY-BOCS Score (SD) | 27.0 (6.3) | 28.4 (7.0) |
| CY-BOCS Score Range | 13–37 | 10–39 |
| MDD, N (%) | 2 (4.3) | 6 (11.8) |
| ADHD, N (%) | 9 (19.6) | 11 (21.6) |
| Anxietyi, N (%) | 20 (43.5) | 26 (51.0) |
| Ticsii, N (%) | 16 (34.8) | 8 (15.7) |
| Controls | ||
| Males | Females | |
| Total N | 51 | 52 |
| Mean Age (SD) | 14.2 (3.4) | 15.4 (3.8) |
| Age Range | 6.2–19.9 | 6.8–19.8 |
| Mean Total ICV (cc) (SD) | 1676.6 (135.1) | 1542.7 (120.9) |
| Mean PDS Score (SD) | 12.0 (3.5) | 13.9 (3.4) |
| PDS Score Range | 4–18 | 5–19 |
N, sample size; 5-HTTLPR, serotonin transporter-linked polymorphic region; SNP, single nucleotide polymorphism; SLC6A4, solute carrier family 6 member 4 (serotonin transporter gene); HTR2A, 5-HT2A receptor gene; HTR1B, 5-HT1B receptor gene; HTR2C, 5-HT2C receptor gene; OCD, obsessive-compulsive disorder; SD, standard deviation; ICV, intracranial volume; PDS, Pubertal Development Scale; cc, cubic centimeters; CY-BOCS, Children’s Yale-Brown Obsessive-Compulsive Scale; MDD, major depressive disorder; ADHD, attention-deficit/ hyperactivity disorder
Includes Separation Anxiety Disorder, Panic Disorder (with or without Agoraphobia Specified), Specific Phobia, Social Phobia, Generalized Anxiety Disorder (GAD)
Includes Tourette’s Disorder, Chronic Motor Tic Disorder, Chronic Vocal Tic Disorder, Transient Tic Disorder (Motor and/or Vocal), Lifetime History of Motor/Vocal Tic