Table 3.

Effect of serotonin gene variants on brain volume in males: Top 20 SNP findings

Brain Region	SNP	Gene	Tested Allele	MAF	SNP Effect (cc)	P value
Caudate	rs7330368	HTR2A	A	0.22	−0.16	2.68E-04
Caudate	rs9316235	HTR2A	A	0.23	−0.17	2.92E-04
Caudate	rs2770297	HTR2A	T	0.26	−0.16	3.87E-04
Caudate	rs61948331	HTR2A	A	0.13	−0.16	4.56E-04
Caudate	rs731779	HTR2A	C	0.11	−0.16	4.60E-04
Caudate	rs9562687	HTR2A	A	0.10	−0.16	4.60E-04
Caudate	rs9562688	HTR2A	A	0.10	−0.16	4.60E-04
Caudate	rs61948356	HTR2A	A	0.14	−0.15	5.11E-04
Caudate	rs61948354	HTR2A	C	0.14	−0.15	5.13E-04
Caudate	rs17287961	HTR2A	T	0.07	−0.16	5.49E-04
Caudate	rs61948357	HTR2A	C	0.14	−0.15	5.61E-04
Caudate	rs73477746	HTR2A	G	0.14	−0.15	5.62E-04
Caudate	rs8078900	SLC6A4	A	0.25	−0.15	6.23E-04
Caudate	rs33980254	SLC6A4	T	0.25	−0.15	6.23E-04
Caudate	rs73268099	SLC6A4	G	0.25	−0.15	6.23E-04
Caudate	rs61647933	HTR2A	C	0.17	−0.15	6.38E-04
Caudate	rs61948335	HTR2A	G	0.11	−0.15	6.42E-04
Caudate	rs61948318	HTR2A	T	0.13	−0.16	6.44E-04
Caudate	rs9534501	HTR2A	T	0.13	−0.16	6.53E-04
Caudate	rs9567743	HTR2A	C	0.13	−0.16	6.53E-04

SNP, single nucleotide polymorphism; MAF, minor allele frequency; cc, cubic centimeters; SLC6A4, solute carrier family 6 member 4 (serotonin transporter gene); HTR2A, 5-HT_2A receptor gene