Table 5.

Effect of genotype-diagnosis interaction on brain volume in males: Top 20 SNP findings

Brain Region	SNP	Gene	Tested Allele	MAF	SNP Main Effect (cc)	SNP P value	Interaction Term Estimate (cc)	Interaction P value
OFC	rs1777764	HTR1B	G	0.31	−0.97	3.52E-01	5.78	1.58E-03
OFC	rs28656158	HTR1B	C	0.31	−0.71	4.81E-01	5.43	2.23E-03
Thalamus	rs17069005	HTR2A	G	0.20	−0.74	4.24E-02	1.47	2.32E-03
Caudate	rs4942577	HTR2A	T	0.38	−0.89	3.02E-04	1.06	3.06E-03
OFC	rs2223832	HTR1B	C	0.14	−2.51	1.17E-01	7.20	3.61E-03
OFC	rs11757592	HTR1B	C	0.14	−2.51	1.17E-01	7.20	3.61E-03
Caudate	rs9534488	HTR2A	T	0.46	−0.69	3.04E-03	0.97	4.44E-03
Caudate	rs9526236	HTR2A	T	0.46	−0.69	3.22E-03	0.98	4.73E-03
OFC	rs9343614	HTR1B	G	0.20	−1.93	1.11E-01	6.22	4.77E-03
Caudate	rs12110491	HTR1B	T	0.12	0.46	2.37E-01	−1.72	4.90E-03
Caudate	rs55636038	HTR1B	T	0.12	0.46	2.37E-01	−1.72	4.90E-03
Caudate	rs11755194	HTR1B	C	0.12	0.46	2.37E-01	−1.72	4.90E-03
Caudate	rs1228798	HTR1B	G	0.12	0.46	2.37E-01	−1.72	4.90E-03
Caudate	rs1228797	HTR1B	T	0.12	0.46	2.37E-01	−1.72	4.91E-03
Caudate	rs2207056	HTR1B	T	0.12	0.46	2.37E-01	−1.72	4.92E-03
Caudate	rs10806097	HTR1B	T	0.12	0.48	2.34E-01	−1.74	5.06E-03
Caudate	rs1228806	HTR1B	C	0.11	0.50	2.36E-01	−1.76	5.47E-03
Caudate	rs17069005	HTR2A	G	0.20	−0.86	7.41E-03	1.17	5.50E-03
Caudate	rs1228805	HTR1B	G	0.11	0.50	2.36E-01	−1.77	5.56E-03
Caudate	rs1228804	HTR1B	G	0.11	0.51	2.38E-01	−1.77	5.74E-03

SNP, single nucleotide polymorphism; MAF, minor allele frequency; cc, cubic centimeters; OFC, orbitofrontal cortex; HTR2A, 5-HT_2A receptor gene; HTR1B, 5-HT_1B receptor gene