Table 6. Rosetting of P. falciparum clone IT/R29 by ABO genotype.
IT/R29 rosette size | ||||
N | Genotype | Mean rosette size | 95% CI | p value |
23 | OO | 2.89 | 2.77–3.01 | - |
18 | AO | 2.92 | 2.78–3.05 | 0.737 |
2 | AA | 3.36 | 2.95–3.78 | 0.030 |
9 | BO | 2.92 | 2.73–3.11 | 0.773 |
1 | BB | 2.52 | 1.93–3.11 | 0.229 |
7 | AB | 3.28 | 3.06–3.50 | 0.003 |
37 | Non-O | 3.00 | 2.92–3.11 | 0.157 |
Frequency of IT/R29 large rosettes | ||||
N | Genotype | % of large rosettes (>4 uninfected RBCs/rosette) | 95% CI | p value |
23 | OO | 8.49 | 5.75–1.22 | - |
18 | AO | 9.36 | 6.27–12.22 | 0.674 |
2 | AA | 20.55 | 11.20–29.91 | 0.016 |
9 | BO | 8.45 | 4.09–12.81 | 0.988 |
1 | BB | 1.29 | -12.01–14.59 | 0.296 |
7 | AB | 18.23 | 13.19–23.28 | 0.001 |
37 | Non-O | 11.27 | 8.89–13.66 | 0.143 |
Differences in IT/R29 rosette size or frequency of large rosettes by ABO genotype were tested using multivariate regression analysis with adjustment for confounding by HbAS. 60 RBC donor samples were tested once in duplicate over two successive experimental days (day 1 n = 30 and day 2 n = 30), therefore, experimental day was included as a co-variate to account for day-to-day variation.