Table 3. Bioinformatic analyses of IL-17F gene.
| Bioinformatics tools | rs2397084 (E126G) | rs11465553 (V155I) | rs763780 (H161R) | |
|---|---|---|---|---|
| PHD SNP (Threshold 0.5) | Prediction | Neutral | Neutral | Neutral |
| Score | 0.145 | 0.381 | 0.138 | |
| SNP& GO (Threshold 0.5) | Prediction | Neutral | Neutral | Neutral |
| Score | 0.145 | 0.159 | 0.050 | |
| SIFT | Prediction | Not-tolerated | Tolerated | Not-tolerated |
| Score | 0.02 | 0.12 | 0.05 | |
| PROVEAN | Prediction | Disease | Neutral | Disease |
| Score | -5.786 | -0.926 | -2.620 | |
| POLYPHEN-2 | Prediction | Probably Damaging | Probably Damaging | Benign |
| Score | 1 | 0.999 | 0.048 | |
| I-Mutant | Prediction | Decrease | Decrease | Decrease |
| Score | 9 | 4 | 5 | |
| ConSurf | Prediction | Highly Conserved and Exposed (F) | Highly Conserved and Exposed (F) | Highly Conserved and Exposed |
| Conservation score | 9 | 8 | 5 | |
| MutPred | Top Features | - | - | LOSS Of Strand (P = 0.05) Altered Transmembrane protein (P = 1.3e-03) Altered Stability (P = 0.03) |
0.0< TM-score < 0.30, random structural similarity 0±0.3 and 0.5 < TM-score < 1.00, in about the same fold 0.5±1.