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. 2020 Mar 30;64(4):418–426. doi: 10.20945/2359-3997000000220

Table 1. Baseline clinical characteristics of patients with T2DM in the studied groups. Data are reported either as the median [25th percentile; 75th percentile] or as a raw number (percentage) within the study group. The p-values are from either Mann-Whitney U-tests or from chi-square tests for categorical variables.

Variable Insulin-treated group (Control) n = 21 Insulin-vildagliptin-treated group (VIG) n = 23 P
Age (years) 60.0 [54.0; 66.0] 62.0 [58.0; 63.0] 0.56
Male, n (%) 9 (42.9%) 9 (39.1%) 0.80
Known diabetes duration (years) 10.0 [6.0; 13.0] 8.0 [7.0; 12.0] 0.72
Fasting blood glucose, mmol/L 6.4 [5.8; 7.4] 6.9 [6.5; 7.3] 0.08
Postprandial blood glucose, mmol/L 7.9 [7.3; 8.9] 8.2 [7.9; 9.1] 0.38
HbA1c, % 7.2 [6.6; 7.6] 7.3 [6.9; 7.6] 0.55
Daily insulin dose, units/kg 0.44 [0.37; 0.63] 0.43 [0.37; 0.54] 0.76
Frequency of hypoglycemic episodes (per month) 1.0 [0.3; 2.0] 1.0 [0.5; 2.0] 0.87
Diabetic neuropathy, n (%) 17 (81.0%) 19 (82.6%) 0.89
Diabetic retinopathy, n (%) 10 (47.6%) 9 (39.1%) 0.57
Diabetic nephropathy, CKD A2 category, n (%) 10 (47.6%) 12 (52.2%) 0.76
BMI, kg/m 2 31.5 [28.0; 35.4] 31.6 [30.3;34.9] 0.56
Total cholesterol, mmol/L 5.4 [4.8; 6.3] 5.5 [4.8; 6.1] 0.81
Triglycerides, mmol/L 1.5 [1.3; 1.9] 1.6 [1.1; 1.9] 0.82
hsCRP, mg/L 3.62 [1.54; 5.40] 2,73 [0.84; 5.20] 0.43

  • Lipid-lowering medication intake,

  • n (%):

  • – statins

  • – fibrates

  • 11 (52.4%)

  • 10 (47.6%)

  • 0

  • 1 (4.8%)

  • 15 (65.2%)

  • 12 (52.2%)

  • 2 (8.7%)

  • 1 (4.3%)

 0.93
Systolic blood pressure, mmHg 132 [125; 139] 133 [128; 138] 0.56
Diastolic blood pressure, mmHg 78 [73; 84] 81 [75; 85] 0.25
Antihypertensive therapy intake, n (%) 17 (81.0%) 20 (86.9%) 0.59
RAS-modulating drugs intake, n (%) 16 (76.2%) 19 (82.6%) 0.60
Clinical manifestation of atherosclerosis, n (%)

  • – ischemic heart disease

  • – a history of myocardial infarction

  • –a history of stroke

  • – extracoronary atherosclerosis

  • 11 (52.4%)

  • 7 (33.3%)

  • 3 (14.3%)

  • 3 (14.3%)

  • 9 (42.8%)

  • 11 (47.8%)

  • 7 (30.4%)

  • 2 (8.7%)

  • 1 (4.3%)

  • 8 (35.0%)

 0.76
Smoking, n (%) 7 (33.3%) 6 (26.1%) 0.59

RAS: renin-angiotensin system; hsCRP: high-sensitivity C-reactive protein; CKD: chronic kidney disease.