Table 1. Descriptive data of body composition on different groups of FGF21 increased and decreased in obese adolescents submitted to multidisciplinary therapy.
| Increase FGF21 | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| < 76.5 pg/mL (n = 13) | ≥ 76.5 pg/mL (n = 14) | |||||
|
|
|
|||||
| Baseline | After | P | Baseline | After | P | |
| Body weight (kg) | 112.4 ± 20.7 | 105.7 ± 18.2† | 0.00 | 111.6 ± 12.8 | 107.0 ± 12.6† | 0.04 |
| BMI (kg/m2) | 37.3 ± 5.3 | 34.9 ± 5.1 | 0.53 | 39.1 ± 4.4 | 37.9 ± 4.6† | 0.02 |
| Body Fat (kg) | 39.5 ± 10.2 | 35.0 ± 8.8 | 0.06 | 44.3 ± 7.1 | 41.2 ± 6.9 | 0.40 |
| FFM (kg) | 72.6 ± 13.4 | 70.7 ± 12.9† | 0.01 | 70.8 ± 9.3 | 69.8 ± 9.3 | 0.85 |
| RMR (kcal) | 2207.7 ± 407.1 | 2148.5 ± 391.1† | 0.00 | 2152.8 ± 284.5 | 2124.9 ± 281.7 | 0.88 |
| FGF21 | 187.5 ± 143.3* | 226.8 ± 137.9† | 0.01 | 97.9 ± 135.5* | 271.4 ± 256.6† | 0.00 |
| Decrease FGF21 | ||||||
| < -64.1 pg/mL (n = 14) | ≥ -64.1 pg/mL (n = 14) | |||||
| Baseline | After | P | Baseline | After | P | |
| Body weight (kg) | 107.2 ± 13.9 | 101.9 ± 13.5† | 0.00 | 112.9 ± 15.8 | 104.9 ± 14.9† | 0.00 |
| BMI (kg/m2) | 37.5 ± 5.1 | 35.4 ± 5.3 | 0.91 | 39.5 ± 4.1 | 36.7 ± 3.8 | 0.25 |
| Body Fat (kg) | 40.2 ± 7.0 | 36.8 ± 6.6 | 0.28 | 45.2 ± 9.5 | 39.3 ± 7.7† | 0.00 |
| FFM (kg) | 66.9 ± 10.8 | 65.1 ± 10.1† | 0.00 | 67.7 ± 10.1 | 65.6 ± 10.2† | 0.00 |
| RMR (kcal) | 2034.8 ± 331.9 | 1979.6 ± 307.5† | 0.01 | 2059.3 ± 308.5 | 1989.7 ± 300.5† | 0.00 |
| FGF21 | 183.9 ± 165.7* | 152.7 ± 168.1 | 0.89 | 426.0 ± 261.0 | 182.0 ± 143.0† | 0.00 |
*p < 0.05 compared to decrease FGF21 ≥ -64.1; †p < 0.05 compared to baseline in the same group. FGF21 were expressed in pg/mL. BMI: body mass index; FFM: free fat mass; RMR: rest metabolic rate.