Table 5.
Univariable and multivariable Cox proportional hazards regression models for the association of spontaneous bacterial peritonitis development risk with PMN percent and count, among those with PMN < 250 cells/mm3 at first paracentesis
| HR (95% CI), P | ||||
| Multivariablea | ||||
| Characteristic at paracentesis | Univariable | Adjusted for baseline characteristics | Adjusted for PMN-C ≥ 115 cells/mm3 | Adjusted for MELD-Nab |
| PMN-% | ||||
| <10% | 1.00 | 1.00 | 1.00 | 1.00 |
| 10%–29% | 1.91 (1.13–3.22), 0.02 | 1.86 (1.10–3.14), 0.02 | 1.86 (1.10–3.14), 0.02 | 1.68 (0.97–2.91), 0.07 |
| ≥30% | 4.11 (2.20–7.66), <0.001 | 3.83 (2.06–7.13), <0.001 | 3.86 (1.88–7.92), <0.001 | 3.48 (1.80–6.72), <0.001 |
| Creatinine (per 1 mg/dL) | 0.78 (0.57–1.06), 0.11 | 0.78 (0.57–1.07), 0.13 | 0.78 (0.57–1.07), 0.13 | — |
| PMN-C ≥ 115 (vs <115 cells/mm3) | 2.33 (1.11–4.86), 0.02 | — | 0.98 (0.41–2.36), 0.97 | — |
| MELD-Na (per 1 unit) | 1.03 (0.99–1.06), 0.10 | — | — | 1.02 (0.99–1.06), 0.18 |
CI, confidence interval; HR, hazard ratio; MELD-Na, Model for End-Stage Liver Disease-Sodium; PMN, polymorphonuclear leukocyte; PMN-%, PMN percentage; PMN-C, PMN count.
a
Multivariable models adjusted for serum creatinine at paracentesis; N = 377 due to missing serum creatinine values.
b
Adjusted for MELD-Na at paracentesis; N = 346 due to missing MELD-Na values.