Table 1.
Clinical and demographic predictors of patients with UC-PSC and UC without PSC
| Clinical/demographic predictors | UC-PSC (n = 57) | UC_without PSC (n = 524) | Univariate OR (95% CI) | Multivariate OR (95% CI)a |
| Male, No. (%) | 32/53 (60.3) | 264 (50.4) | 1.43 (0.81–2.52) P = 0.21 |
NA |
| Family history of IBD, No. (%) | 9 (15.8) | 100 (19.1) | 0.79 (0.38–1.67) P = 0.53 |
NA |
| Age at UC diagnosis, yr, mean (SD) <20 yr, No. (%) |
24.8 (11.5) 23 (40.4) |
33.6 (14.2) 78 (14.9) |
P = 1.01E-06 3.83 (2.14–6.85) P = 1.51E-05 |
2.22 (1.16–4.25) P = 0.02 |
| Disease duration, yr, mean (SD) | 21.8 (12.1) | 11.7 (8.7) | P = 1.76E-11 | P = 4.42E-09 |
| Ever smoking, No. (%) | 8 (14.0) | 157 (30.0) | 0.38 (0.18–0.82) P = 0.007 |
0.42 (0.19–0.96) P = 0.02 |
| Bowel resection, No. (%) | 16 (28.1) | 133 (25.4) | 1.13 (0.61–2.08) P = 0.69 |
NA |
| Extensive disease (pancolitis), No. (%) | 53 (93.0) | 355 (67.7) | 5.97 (2.12–16.7) P = 1.92E-05 |
5.42 (1.87–15.7) P = 1.57E-04 |
| Extraintestinal manifestations, No. (%) | NA | |||
| Eye | 1 (1.8) | 10 (1.9) | P = 0.91 | |
| Skin | 2 (3.5) | 14 (2.7) | P = 0.75 | |
| Joint | 6 (10.5) | 66 (12.6) | P = 0.61 |
IBD, inflammatory bowel disease; NA, not available; OR, odds ratio; PSC, primary sclerosing cholangitis; UC, ulcerative colitis.
a
Multivariate analysis included age at UC, diagnosis, disease duration, ever smoking, and extensive disease (pancolitis).