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. 2023 Jul 24;41(27):4369–4380. doi: 10.1200/JCO.23.00062

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FIG 4. — Time to pelvic recurrence per molecular class in PORTEC-2. (A) Time to pelvic recurrence in POLE-mutated endometrial cancer. (B) Time to pelvic recurrence in mismatch-repair deficient endometrial cancer. (C) Time to pelvic recurrence in p53 abnormal endometrial cancer. (D) Time to pelvic recurrence in no specific molecular profile endometrial cancer. EBRT, external beam radiotherapy; EC, endometrial cancer; MMRd EC, EC with mismatch repair deficiency (POLE wild-type); NSMP EC, EC with no specific molecular profile (POLE wild-type, MMR-proficient, and p53 wild-type); POLEmut EC, EC with a pathogenic mutation of DNA polymerase-ε; p53abn EC, EC with a p53 abnormality (POLE wild-type and MMR-proficient); VBT, vaginal brachytherapy.