Table 2. Relationship of pTERT/BRAFV600E mutation and clinicopathologic aspects in 45 thyroid nodules specimens obtained by fine needle aspiration and postoperatively confirmed as papillary thyroid carcinoma.
| Variables | BRAF status, n (%) | P value | TERT status, n (%) | P value | |||
|---|---|---|---|---|---|---|---|
| Wild type | Mutated | Wild type | Mutated | ||||
| Gender | |||||||
| Male | 1 (6.7) | 5 (16.7) | 0.647 | 5 (12.2) | 1 (25.0) | 0.448 | |
| Female | 14 (93.3) | 25 (83.3) | 36 (87.8) | 3 (75.5) | |||
| Age, mean (sd) | 44.0 (14.35) | 50.7 (14.0) | 0.139 | 46.9 (13.5) | 64.0 (15.3) | 0.022 | |
| Tumor size | |||||||
| ≤ 1 cm | 3 (21.4) | 10 (33.3) | 0.498 | 13 (32.5) | 0 (0.0) | 0.302 | |
| > 1 cm | 11 (78.6) | 20 (66.7) | 27 (67.5) | 4 (100.0) | |||
| Multicentricity | |||||||
| Absent | 12 (80.0) | 22 (73.3) | 0.726 | 30 (73.2) | 4 (100.0) | 0.558 | |
| Present | 3 (20.0) | 8 (26.7) | 11 (26.8) | 0 (0.0) | |||
| Extrathyroid extension | |||||||
| Absent | 14 (93.3) | 27 (90.0) | 1.00 | 38 (92.7) | 3 (75.0) | 0.320 | |
| Present | 1 (6.7) | 3 (10.0) | 3 (7.3) | 1 (25.0) | |||
| Lymphnode metastases | |||||||
| Absent | 14 (93.3) | 24 (80.0) | 0.395 | 36 (87.8) | 2 (50.0) | 0.108 | |
| Present | 1 (6.7) | 6 (20.0) | 5 (12.2) | 2 (50.0) | |||
| AJCC stage | |||||||
| I+II | 12 (85.7) | 21 (70.0) | 0.456 | 33 (82.5) | 0 (0.0) | 0.002 | |
| III+IV | 2 (14.3) | 9 (30.0) | 7 (17.5) | 4 (100.0) | |||
| Capsular invasion | |||||||
| Absent | 13 (86.7) | 24 (80.0) | 0.699 | 34 (82.9) | 3 (75.0) | 0.557 | |
| Present | 2 (13.3) | 6 (20.0) | 7 (17.1) | 1 (25.0) | |||