Table 3. Correlation of pTERT/BRAFV600E mutations and clinicopathologic aspects in 45 thyroid nodules specimens obtained by fine needle aspiration and postoperatively confirmed as papillary thyroid carcinoma.
| Variables | BRAF/TERT status, n (%) | |||
|---|---|---|---|---|
| BRAF-/TERT- | BRAF+/TERT- | BRAF+/TERT+ | ||
| Gender | ||||
| Male | 14 (93.3) | 22 (84.6) | 3 (75.0) | |
| Female | 1 (6.7) | 4 (15.4) | 1 (25.0) | |
| P valuea = 0.407 | P valueb = 0.636 | P valuec = 0.386 | ||
| Age, mean (sd) | 44.0 (14.35) | 48.7 (12.9) | 64.0 (15.3) | |
| P valuea = 0.042 | P valueb = 0.881 | P valuec = 0.037 | ||
| Tumor size | ||||
| ≤ 1 cm | 3 (21.4) | 10 (38.5) | 0 (0.0) | |
| > 1 cm | 11 (78.6) | 16 (61.5) | 4 (100.0) | |
| P valuea = 0.284 | P valueb = 0.316 | P valuec = 1.00 | ||
| Multicentricity | ||||
| Absent | 12 (80.0) | 18 (69.2) | 4 (100.0) | |
| Present | 3 (20.0) | 8 (30.8) | 0 (0.0) | |
| P valuea = 0.592 | P valueb = 0.716 | P valuec = 1.00 | ||
| Extrathyroid extension | ||||
| Absent | 14 (93.3) | 24 (92.3) | 3 (75.0) | |
| Present | 1 (6.7) | 2 (7.7) | 1 (25.0) | |
| P valuea = 0.509 | P valueb = 1.00 | P valuec = 0.386 | ||
| Lymphnode metastases | ||||
| Absent | 14 (93.3) | 22 (84.6) | 2 (50.0) | |
| Present | 1 (6.7) | 4 (15.4) | 2 (50.0) | |
| P valuea = 0.139 | P valueb = 0.636 | P valuec = 0.097 | ||
| AJCC stage | ||||
| I+II | 12 (85.7) | 21 (80.8) | 0 (0.0) | |
| III+IV | 2 (14.3) | 5 (19.2) | 4 (100.0) | |
| P value a = 0.004 | P valueb = 1.00 | P valuec = 0.005 | ||
| Capsular invasion | ||||
| Absent | 13 (86.7) | 21 (80.8) | 3 (75.0) | |
| Present | 2 (13.3) | 5 (19.2) | 1 (25.0) | |
| P valuea = 0.861 | P valueb = 1.00 | P valuec = 0.530 | ||
a
Global test.
b
BRAF-/TERT- vs BRAF+/TERT- comparasion.
c
BRAF-/TERT- vs BRAF+/TERT+ comparasion.