Table 1. Baseline clinical and biochemical data.
| Prior to randomization (n = 32) | Group 1 (G1) (n = 17) | Group 2 (G2) (n = 15) | P (group 1 vs. group 2) | |
|---|---|---|---|---|
| Age (years-old) | 42.6 ± 13.3 | 39.5 ± 14.2 | 46.1 ± 11.86 | 0.170 |
| Gender (F:M) | 30:2 | 15:2 | 15:0 | 0.143 |
| Participants on LT4 125 μg/day (%) | 50 | 52.9 | 46.7 | 0.726 |
| Time of hypothyroidism diagnosis (years) | 4.5 (1 – 33) | 5 (1 – 33) | 4 (1 – 23) | 0.595 |
| Autoimmune/idiopathic hypothyroidism (%) | 71.9 | 58.8 | 86.7 | 0.080 |
| Post-surgical hypothyroidism (%) | 18.7 | 23.5 | 13.3 | 0.460 |
| Radioiodine-induced hypothyroidism (%) | 9.4 | 17.6 | 0 | 0.088 |
| Body mass index (kg/m2) | 28.5 ± 5.6 | 27.3 ± 5.0 | 29.8 ± 6.0 | 0.211 |
| Resting heart rate (beats per minute) | 76.7 ± 9.8 | 79.1 ± 9.0 | 74.1 ± 10.3 | 0.160 |
| Systolic blood pressure (mmHg) | 120.0 (90.0 – 150.0) | 120.0 (100.0 – 140.0) | 120.0 (90.0 – 150.0) | 0.612 |
| Diastolic blood pressure (mmHg) | 78.9 ± 11.3 | 77.1 ± 11.2 | 81.0 ± 11.5 | 0.335 |
| TSH (mU/L) | 0.309 (0.001 – 8.425) | 0.078 (0.001 – 4.500) | 0.535 (0.001 – 8.425) | 0.117 |
| Total T3 (ng/dL) | 93.6 ± 11.6 | 93.2 ± 11.6 | 94.0 ± 12.0 | 0.847 |
| Free T4 (ng/dL) | 1.26 ± 0.26 | 1.26 ± 0.25 | 1.26 ± 0.28 | 0.956 |
| Glucose (mg/dL) | 99.0 ± 12.5 | 97.6 ± 10.6 | 100.5 ± 14.5 | 0.532 |
| Total cholesterol (mg/dL) | 191.1 ± 35.4 | 188.8 ± 36.9 | 193.7 ± 34.8 | 0.706 |
| HDL (mg/dL) | 47.2 ± 11.9 | 47.5 ± 12.4 | 46.9 ± 11.8 | 0.891 |
| Triglycerides (mg/dL) | 139.7 ± 68.0 | 144.5 ± 75.0 | 134.3 ± 61.2 | 0.679 |
Note: results are shown as mean ± standard deviation or median (minimum – maximum).