Table 1. Comparison of the demographic, biochemical and imaging data of the patients in three histological subgroups.
| Classic (n = 102) | Atypical (n = 23) | Carcinoma (n = 5) | p-value | |
|---|---|---|---|---|
| Mean age (years) | 51.1 ± 14.0 | 51.3 ± 13.7 | 50.4 ± 13.7 | 0.991† |
| Male/Female | 20/80 (20.0-80%)a | 11/12 (47.8-52.2%)a | 3/2 (60.0-40%) | 0.006 ‡ |
| Median Ca (mg/dL) | 11.3 (9.2-14.7)b | 11.6 (10-16)c | 16.0 (11.6-16.5)b,c | 0.005 ¶ |
| Median P (mg/dL) | 2.5 (1.1-4.5) | 2.3 (2.5-2.9) | 2.1 (1.4-3.5) | 0.370¶ |
| Median PTH (pg/mL) | 167.5 (60-900)a,b | 448.0 (139-735)a | 520.0 (163-1077)b | < 0.001 ¶ |
| Median ALP (IU/L) | 101.0 (27-244)a,b | 190.0 (66-718)a | 589.0 (119-1880)b | < 0.001 ¶ |
| Median urine Ca (mg/day) | 370.5 (68-948)a,b | 500.0 (362.0)a | 500.0 (483-900)b | 0.002 ¶ |
| Mean 25-OH-Vit D (ng/mL) | 13.47 ± 0.39 | 12.84 ± 0.47 | 11.57 ± 0.34 | 0.072 |
| Median serum creatinine mg/dL | 0.6 (0.4-1.2) | 0.8 (0.5-1.8) | 1.0 (0.6-1.9) | 0.087 |
| Median femur neck T score* | -1.06 (-3. 9-1.1)a,b | -1.90 (-3.2- 0.2)a | -2.8 (-3.7-0.1)b | 0.006 |
| Median lumbar spine T score* | -1.63 (-5.3-1.1) | -2.38 (-5.5-0.3) | -2.45 (-5.8-0.8) | 0.13 |
| Median lesion diameter (mm) | 14.5 (5-43)a,b | 22.0 (5-58)a | 32.0 (15-44)b | < 0.001 ¶ |
| USG | < 0.001 ‡ | |||
| Hypoechoic | 95 (95.0%)a,b | 15 (65.2%)a | 1 (20.0%)b | |
| Isoechoic | 3 (3.0%)a,b | 5 (21.7%)a | 3 (60.0%)b | |
| Cystic | 2 (2.0%)a | 3 (13.0%)a | 1 (20.0%) | |
| Positive MIBI | 63 (65.6%) | 18 (78.3%) | 5 (100.0%) | 0.158‡ |
| Persistent/Recurrent disease | 3 (3.0%)b | 1 (4.3%)c | 3 (60.0%)b,c | < 0,001 ‡ |
† One-Way ANOVA; ‡ Chi-square test; ¶ Kruskal Wallis test; a: Classic vs Atypical (p < 0.05); b: Classic vs carcinoma (p < 0.05); c: atypical vs carcinoma (p = 0.010). * Z score was used for premenouposal females and males younger than 50 years of age.