Table 4. Cytokines levels according to genotypes in T2DM patients group.
| Polymorphism | Cytokine (fg/mL) | p | p’ | |
|---|---|---|---|---|
| TNF-α (-308 G/A) (rs1800629) | GG (n = 78) | 95 (45) | 0.137 | - |
| GA (n = 23) | 85 (44) | |||
| AA (n = 1) | 47.5† | |||
| IL-6 (-174 C/G) (rs1800795) | CC1 (n = 7) | 1901 (3167) | 0.026* | pa = 0.047 |
| CG2 (n = 26) | 496 (746) | pb = 0.210 | ||
| GG3 (n = 69) | 878 (945) | pc = 0.023 | ||
| IL-10 (-1082 G/A) (rs1800896) | GG (n = 12) | 202 (62) | 0.181 | - |
| GA (n = 47) | 178 (68) | |||
| AA (n = 43) | 199 (87) | |||
| IL-10 (-819 T/C) (rs1800871) | TT1 (n = 13) | 256 (207) | 0.021* | pa = 0.066 |
| TC2 (n = 40) | 184 (90) | pb = 0.006* | ||
| CC3 (n = 49) | 182 (57) | pc = 0.207 | ||
| IL-10 (-592 A/C) (rs1800872) | AA (n = 14) | 249 (212) | 0.055 | - |
| AC (n = 39) | 185 (91) | |||
| CC (n = 49) | 182 (57) | |||
TNF-α: tumor necrosis factor-alpha; IL-6: interleukin-6; IL-10: interleukin-10.
Cytokine levels: no normal variable; the data are shown as “median (IQR)”.
* p < 0.05 was considered statistically significant.
* p’ < 0.02 was considered statistically significant (Mann-Whitney test with Bonferroni’s Correction).
pa: genotype 1 versus genotype 2.
pb: genotype 1 versus genotype 3.
pc: genotype 2 versus genotype 3.
† data only one individual.