FIGURE 3.

FLIm provides optical contrast between astrocytoma and oligodendroglioma. (A) Surgical field-of-view of representatives of oligodendroglioma (left) and astrocytoma (right) tumors with 470-nm lifetime overlaid in the scanned regions and the corresponding H&E scan (×40 magnification). (B) Average lifetimes of tumor tissue from astrocytoma (teal) and oligodendroglioma (orange) across the three spectral channels. (C) ROC curves computed for the data point-level identification of astrocytoma from oligodendroglioma tumors for the 390-nm, 470-nm, and 542-nm lifetimes. (D) Average lifetimes of tumor tissue from different grades of astrocytoma and oligodendroglioma samples across the three spectral channels. Each point corresponds to the median of each scan. The mean and standard deviation of each tissue group are indicated by the error bars. *p-value <0.01; non-significant statistics are left unmarked. N indicates the number of patients; n indicates the number of scans.