Table 4. Distribution by gender of RAS genotypes and alleles in Chilean subjects with and without metabolic syndrome.
Sex | Genotype | No MetS | MetS | Odds ratio, CI (95%) | p-value | p-value Adjusted* |
---|---|---|---|---|---|---|
rs4340 | ||||||
Women | II | 23 (44.2) | 20 (37.0) | 1.35 (0.62-2.94) | 0.55 | 0.33 |
ID | 25 (48.1) | 19 (35.2) | 0.59 (0.27-1.28) | 0.24 | < 0.01 | |
DD | 4 (7.7) | 15 (27.8) | 4.62 (1.41-15.04) | 0.01 | < 0.01 | |
I | 71 (68.3) | 59 (54.6) | 1.79 (1.02-3.13) | 0.048 | ||
D | 33 (31.7) | 49 (45.4) | ||||
Men | II | 4 (23.5) | 12 (41.4) | 0.44 (0.11-1.67) | 0.33 | 0.20 |
ID | 10 (58.8) | 14 (48.3) | 0.65 (0.19-2.19) | 0.55 | 0.40 | |
DD | 3 (17.6) | 3 (16.3) | 0.54 (0.09-3.03) | 0.65 | 0.44 | |
I | 18 (52.9) | 38 (65.5) | 0.59 (0.25-1.41) | 0.27 | ||
D | 16 (47.1) | 20 (34.5) | ||||
rs699 | ||||||
Women | TT | 6 (11.8) | 7 (13.0) | 0.89 (0.28-2.87) | 1.00 | 0.95 |
CT | 25 (49.0) | 29 (53.7) | 1.21 (0.56-2.59) | 0.69 | 0.89 | |
CC | 20 (39.2) | 18 (33.3) | 0.79 (0.35-1.72) | 0.68 | 0.66 | |
T | 37 (36.3) | 43 (39.8) | 0.86 (0.49-1.50) | 0.67 | ||
C | 65 (63.7) | 65 (60.2) | ||||
Men | TT | 3 (18.8) | 4 (13.8) | 1.44 (0.27-7.44) | 0.68 | 0.74 |
CT | 7 (43.8) | 14 (48.3) | 1.20 (0.35-4.09) | 1.00 | 0.92 | |
CC | 6 (37.5) | 11 (37.9) | 1.02 (0.29-3.59) | 1.00 | 0.93 | |
T | 13 (40.6) | 22 (37.9) | 1.12 (0.46-2.71) | 0.82 | ||
C | 19 (59.4) | 36 (62.1) | ||||
rs5186 | ||||||
Women | AA | 32 (61.5) | 30 (55.5) | 1.28 (0.59-2.78) | 0.55 | 0.56 |
AC | 18 (34.6) | 19 (43.2) | 1.03 (0.46-2.28) | 1.00 | 0.48 | |
CC | 2 (3.9) | 5 (9.3) | 2.55 (0.47-13.78) | 0.43 | 0.23 | |
A | 82 (78.8) | 79 (73.1) | 1.37 (0.73-2.58) | 0.34 | ||
C | 22 (21.2) | 29 (26.9) | ||||
Men | AA | 5 (31.3) | 15 (51.7) | 0.42 (0.11-1.53) | 0.22 | 0.22 |
AC | 10 (62.5) | 14 (48.3) | 0.56 (0.16-1.95) | 0.53 | 0.20 | |
CC | 1 (6.3) | 0 (0.0) | NC | 0.36 | 0.15 | |
A | 20 (62.5) | 44 (75.9) | 0.53 (0.21-1.35) | 0.20 | ||
C | 12 (37.5) | 14 (24.1) |
MetS: metabolic syndrome; No MetS: no metabolic syndrome. * P-value adjusted for age.