Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 28;8(10):1911–1919. doi: 10.1038/s41564-023-01461-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a, Pairwise IBD sharing across all three regions of Ethiopia. The plot shows the probability that any two isolates are identical by descent, where the x axis indicates IBD values ranging 0–1 and the y axis indicates the frequency (%) of isolates sharing IBD. The inset highlights highly related parasite pairs from out of total pairs (n = 44,883), with a heavy tail in the distribution and some highly related pairs of samples having IBD ≥ 0.95. b, Pairwise IBD sharing within parasites carrying K13 622I vs wild type (P < 0.001, two-tailed, Mann–Whitney U-test). Boxes indicate the interquartile range, the line indicates the median, the whiskers show the 95% confidence intervals and black dots show outlier values. P value determined using Mann–Whitney test is shown. c, Relatedness network of highly related parasite pairs (n = 150) sharing IBD ≥ 0.95. Colours correspond to K13 622I mutant and wild parasites. d, Relatedness network of only K13 622I parasite pairs (n = 31) sharing IBD ≥ 0.95 at the district level/local scale. Colours correspond to districts across three regions in Ethiopia. In both c and d, each node identifies a unique isolate and an edge is drawn between two isolates if they share their genome above IBD ≥ 0.95. Isolates that do not share IBD ≥ 0.95 of their genome with any other isolates are not shown.