Table 2.
Patients’ characteristics at ECMO day 1 according to diaphragm dysfunction at ECMO day 1
| Variables | All patients (n = 63) | Diaphragm dysfunction (n = 39) | No diaphragm dysfunction (n = 24) | P value |
|---|---|---|---|---|
| Ventilator settings | ||||
| Tidal volume, ml/kg PBW | 2.8 (2.2–3.7) | 2.7 (2.2–3.6) | 3.0 (2.1–3.8) | 0.488 |
| Respiratory rate, /min | 20 (20–23) | 20 (20–22) | 21 (20–23) | 0.721 |
| Driving pressure, cmH2O | 14 (13–14) | 14 (12–14) | 14 (12–14) | 0.566 |
| Positive end-expiratory pressure, cmH2O | 12 (12–14) | 12 (12–14) | 12 (12–14) | 0.508 |
| Respiratory system compliance, mL/cmH2O | 14 (10–18) | 13 (10–18) | 16 (10–20) | 0.440 |
| Plateau pressure, cmH2O | 26 (24–28) | 26 (24–28) | 26 (25–28) | 0.833 |
| Hemodynamics | ||||
| Heart rate, min−1 | 81 (64–93) | 83 (65–94) | 74 (63–89) | 0.423 |
| Mean arterial pressure, mmHg | 73 (68–80) | 73 (68–78) | 74 (71–80) | 0.162 |
| Norepinephrine, µ/kg/min | 0.1 (0.0–0.34) | 0.1 (0.0–0.4) | 0.1 (0.0–0.3) | 0.658 |
| Arterial blood lactate, mmol/L | 1.8 (1.5–2.3) | 1.8 (1.5–2.4) | 1.8 (1.4–2.1) | 0.577 |
| Fluid balance of the last 24 h, ml | − 151 (− 709–1137) | 115 (− 753–1358) | − 252 (− 675–244) | 0.489 |
| Creatinine, µmol/l | 78 (62–127) | 94 (67–171) | 71 (49–99) | 0.028 |
| Lung ultrasound Score | 26 (23–27) | 26 (24–28) | 25 (22–26) | 0.008 |
| White cells count, G/l | 16 (12–20) | 16 (12–21) | 15 (10–20) | 0.577 |
| Procalcitonin, ng/l | 0.6 (0.3–3.7) | 1.1 (0.3–3.0) | 0.6 (0.2–4.1) | 0.326 |
| Cumulated dose of sedation | ||||
| Propofol, mg/day | 4800 (3600–5310) | 4800 (3600–4800) | 4800 (4500–6000) | 0.075 |
| Sufentanyl, µg/day | 480 (360–600) | 480 (360–600) | 480 (360–600) | 0.691 |
| Midazolam, mg/day | 480 (360–600) | 480 (360–540) | 480 (367–600) | 0.664 |
PBW predicted body weight