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. 2023 Sep 26;14:5995. doi: 10.1038/s41467-023-41608-9

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic timeline highlighting the recruitment of immune cells from innate and adaptive immune systems in Ctrl_LW (top) and ECM_LW (bottom) groups. b Comparison of overall cell-cell interaction numbers of immune cells and cutaneous cells between Ctrl_LW and ECM_LW using CellChat. c The ligand–receptor pairs up-regulated in the Ctrl_LW group in specificity between AIM¹ and fibroblasts (MF¹, RF¹, and LF¹). d The ligand–receptor pairs up-regulated in the ECM_LW group in specificity between Treg¹, MAC (Mono¹, PIM¹, AIM¹), and HFSC¹. e Spatial feature plots and corresponding violin plots showed the expression level of the ligand and cognate receptor in the Notch signaling pathway.