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. 2023 Sep 26;14:6009. doi: 10.1038/s41467-023-41677-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Statistically stable biological mechanisms in PD show significant receptor-mediated contributions. The angle of each outer sector is proportional to the mean weight of each stable (99% confidence interval) re-MCM model weight across the PD patients. The inner sectors represent the 6 modeled biological factors. Within each factor, the intermediate sectors represent the neurotransmitter system involved, while the outer sector consists of the specific two-way receptor-pathology interactions or direct predictor terms in the model. Notably, biological factors may appear as both model predictors (outer sector) and targets (inner sector). b Effect size (number of chords) of statistically stable interactions between any pair of biological factors modeled in PD.