Fig. 6. Distinct combinations of receptor-mediated interactions are associated with the two axes of clinical symptoms.

Biological mechanisms correlated with clinical severity in PD via the (a)motor/psychomotor and (b) visuospatial/memory/psychiatric axes are plotted. Representing the effects of receptor densities, local pathology, receptor-pathology interactions, and network propagation of pathological factors, combinations of patient-specific mechanisms co-vary with specific clinical symptoms. Sector colors represent the output pathological factor of each model, named in the inner (central) sectors. For each mechanism, the angle is proportional to the percentage of mechanistic-clinical covariance explained. The outer sector contains the specific mechanisms, while the middle sector is grouped by receptor families and the inner sector by target biological factor.