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. 2023 Sep 26;13:16070. doi: 10.1038/s41598-023-43423-0

Table 7.

Experimental and predicted values of pharmacokinetic parameters for oral chewable tablets of ciprofloxacin.

Pharmacokinetic parameters IV bolus IR chewable tablets adults Fasted State
Observed31 Simulated FE Observed Simulated FE
Cmax (mcg/ml) 5.7909 7.748 1.34 1.149 1.0624 0.92
Tmax (h) 0.0825 0.072 0.87 1.01 1.6533 1.64
AUC0–inf (mcg-h/ml) 8.8293 10.462 1.18 5.4589 7.5131 1.38
AUC0–t (mcg-h/ml) 8.0045 8.9597 1.12 5.0798 6.746 1.33
Pharmacokinetic parameters IR chewable tablets adults Fed State IR chewable tablets Paeds
Observed Simulated FE Observed38 pH 1.2 (FE) pH 4.5 (FE) pH 6.8 (FE)
Cmax (mcg/ml) 1.165 0.89971 0.77 2.10 2.008 (1.04) 1.9263 (1.09) 1.7394 (1.207)
Tmax (h) 1.5 2.5067 1.67 1.00 2.1333 (0.468) 2.08 (0.481) 1.9733 (0.507)
AUC0–inf (mcg-h/ml) 5.745 7.5968 1.32 5.30 17.151 (0.309) 16.076 (0.329) 13.709 (0.387)
AUC0–t (mcg-h/ml) 5.3605 6.7379 1.26 14.329 13.434 11.466