Table 1.
The alteration observed in the molecular species of 25 most discriminating (according to one-way ANOVA) phospholipid species from PEo, PC, PI and SM class in non-irradiated (melanocytes), irradiated with UVA (melanocytes + UVA) and treated with cannabidiol [CBD (5 µM)], cannabigerol [CBG (1 µM)] or both phytocannabinoids (CBG + CBD).
| Melanocytes | ||||||
|---|---|---|---|---|---|---|
| PL class | Phospholipid specie | Phospholipid molecular specie | Fold-change | |||
| UVA vs control | UVA + CBD vs UVA | UVA + CBG vs UVA | UVA + CBGCBG + CBD vs UVA | |||
| PE | PEo(36:1) | PE(O-18:0/18:1) | 1.06 ↑ | 0.38 ↓ | 1.46 ↑ | 2.05 ↑ |
| PE | PEo(34:1) | PE(O-16:0/18:1) | 0.92 ↑ | 0.52 ↓ | 0.69 ↑ | 1.27 ↑ |
| PE | PEo(34:2) | PE(O-16:0/18:2) | 0.93 ↑ | 0.63 ↓ | 0.19 ↑ | 0.69 ↑ |
| PE | PEo(34:3) | PE(O-16:0/18:3) | 0.99 ↑ | 0.55 ↓ | 0.30 ↑ | 0.88 ↑ |
| PE | PEo(36:3) | PE(O-16:0/20:3) | 0.93 ↑ | 0.46 ↓ | 0.49 ↑ | 1.06 ↑ |
| PE | PEo(40:4) | PE(O-18:0/22:4) | 0.89 ↑ | 0.42 ↓ | 0.22 ↑ | 0.79 ↑ |
| PE | PEo(38:4) | PE(O-16:0/22:4) | 1.05 ↑ | 0.48 ↓ | 0.16 ↑ | 0.63 ↑ |
| PE | PEo(38:6) | PE(O-16:0/22:6) | 0.95 ↑ | 0.98 ↓ | 0.71 ↑ | 0.12 ↓ |
| PE | PEo(36:5) | PE(O-16:0/20:5) | 1.01 ↑ | 0.75 ↓ | 0.57 ↑ | 0.10 ↑ |
| PE | PEo(40:5) | PE(O-18:0/22:5) | 0.97 ↑ | 0.70 ↓ | 0.40 ↑ | 0.19 ↑ |
| SM | SM(d42:2) | SM(d18:1/24:1) | 1.43 ↑ | 0.85 ↓ | 0.66 ↓ | 1.06 ↓ |
| PC | PC(34:0) | PC(16:0/18:0) | 1.40 ↑ | 0.49 ↓ | 0.88 ↓ | 1.14 ↓ |
| PC | PC(32:1) | PC(16:0/16:1) | 1.46 ↑ | 0.59 ↓ | 0.97 ↓ | 1.36 ↓ |
| PC | PC(40:4) | PC(18:0/22:4) | 1.38 ↑ | 0.59 ↓ | 0.98 ↓ | 1.13 ↓ |
| PC | PC(42:2) | PC(24:0/18:2) | 1.34 ↑ | 0.54 ↓ | 0.92 ↓ | 1.16 ↓ |
| PC | PC(38:4) | PC(16:0/22:4) | 1.27 ↑ | 0.99 ↓ | 1.32 ↓ | 1.54 ↓ |
| PC | PC(38:6) | PC(16:0/22:6) | 1.17 ↑ | 0.30 ↓ | 0.68 ↓ | 1.11 ↓ |
| SM | SM(d42:3) | SM(d18:2/24:1) | 1.40 ↑ | 0.80 ↓ | 1.51 ↓ | 1.96 ↓ |
| PI | PI(40:7) | PI(18:1/22:6) | 2.08 ↑ | 1.19 ↓ | 0.44 ↓ | 0.71 ↓ |
| PC | PC(36:4) | PC(16:0/20:4) | 1.48 ↑ | 1.07 ↓ | 1.45 ↓ | 0.92 ↓ |
| PC | PC(40:6) | PC(18:0/22:6) | 1.21 ↑ | 0.77 ↓ | 1.16 ↓ | 1.38 ↓ |
| PI | PI(38:4) | PI(18:0/20:4) | 2.10 ↑ | 1.66 ↓ | 2.61 ↓ | 0.98 ↓ |
| PI | PI(40:4) | PI(18:0/22:4) | 2.06 ↑ | 1.73 ↓ | 1.89 ↓ | 1.59 ↓ |
| PI | PI(40:6) | PI(18:0/22:6) | 1.99 ↑ | 2.21 ↓ | 0.91 ↓ | 2.67 ↓ |
| PI | PI(36:4) | PI(16:0/20:4) | 2.05 ↑ | 2.28 ↓ | 2.44 ↓ | 2.77 ↓ |