Table 2.
The alteration observed in the molecular species of 25 most discriminating (according to One-way ANOVA) phospholipid species from PEo, PC, PI and SM class in non-irradiated SK-MEL-5 cells (SK-MEL-5), irradiated with UVA (SK-MEL-5 + UVA) and treated with cannabidiol [CBD (5 µM)], cannabigerol [CBG (1 µM)] or both phytocannabinoids (CBG + CBD).
| SK-MEL-5 cells | ||||||
|---|---|---|---|---|---|---|
| PL class | Phospholipid specie | Phospholipid molecular specie | Fold-change | |||
| UVA vs control | UVA + CBD vs UVA | UVA + CBG vs UVA | UVA + CBG + CBD vs UVA | |||
| PC | PC(34:0) | PC(16:0/18:0) | 0.39 ↑ | 1.27 ↓ | 3.01 ↓ | 1.87 ↓ |
| PC | PC(38:5) | PC(16:0/22:5) | 1.24 ↑ | 1.64 ↓ | 3.05 ↓ | 2.10 ↓ |
| PC | PC(38:6) | PC(16:0/22:6) | 1.73 ↑ | 1.71 ↓ | 3.93 ↓ | 3.16 ↓ |
| PC | PC(32:1) | PC(16:0/16:1) | 1.79 ↑ | 1.57 ↓ | 2.81 ↓ | 2.82 ↓ |
| PC | PC(38:2) | PC(18:0/20:2) | 2.20 ↑ | 2.04 ↓ | 3.62 ↓ | 3.62 ↓ |
| PC | PC(40:4) | PC(18:0/22:4) | 1.72 ↑ | 2.18 ↓ | 3.85 ↓ | 3.53 ↓ |
| PC | PC(40:6) | PC(18:0/22:6) | 1.19 ↑ | 1.29 ↓ | 3.96 ↓ | 4.05 ↓ |
| PC | PC(40:2) | PC(18:0/22:2) | 1.05 ↑ | 1.25 ↓ | 3.76 ↓ | 4.07 ↓ |
| PC | PC(40:5) | PC(18:0/22:5) | 0.89 ↑ | 1.31 ↓ | 4.03 ↓ | 3.47 ↓ |
| PC | PC(32:0) | PC(16:0/16:0) | 0.33 ↑ | 1.33 ↓ | 3.10 ↓ | 2.74 ↓ |
| PC | PC(38:3) | PC(18:0/20:3) | 1.87 ↑ | 1.61 ↓ | 4.72 ↓ | 4.48 ↓ |
| PC | PC(36:3) | PC(16:0/20:3) | 1.38 ↑ | 1.35 ↓ | 3.30 ↓ | 3.14 ↓ |
| PI | PI(38:6) | PI(16:0/22:6) | 8.36 ↑ | 7.11 ↓ | 13.60 ↓ | 6.77 ↓ |
| PI | PI(36:2) | PI(18:0/18:2) | 7.26 ↑ | 2.73 ↓ | 6.58 ↓ | 6.92 ↓ |
| PI | PI(40:5) | PI(18:0/22:5) | 7.17 ↑ | 0.10 ↑ | 5.53 ↓ | 6.25 ↓ |
| PI | PI(36:0) | PI(18:0/18:0) | 8.71 ↑ | 6.27 ↓ | 8.18 ↓ | 7.88 ↓ |
| PI | PI(38:2) | PI(18:0/20:2) | 7.29 ↑ | 4.91 ↓ | 6.29 ↓ | 6.63 ↓ |
| PI | PI(38:7) | PI(16:1/22:6) | 8.32 ↑ | 6.11 ↓ | 7.23 ↓ | 6.07 ↓ |
| PI | PI(38:3) | PI(18:0/20:3) | 8.01 ↑ | 5.12 ↓ | 6.61 ↓ | 5.32 ↓ |
| PI | PI(36:3) | PI(18:0/18:3) | 7.43 ↑ | 3.62 ↓ | 5.05 ↓ | 4.03 ↓ |
| PI | PI(40:6) | PI(18:0/22:6) | 7.67 ↑ | 4.56 ↓ | 5.98 ↓ | 5.88 ↓ |
| SM | SM(d42:3) | SM(d18:2/24:1) | 7.23 ↑ | 3.11 ↓ | 3.11 ↓ | 3.57 ↓ |
| PI | PI(34:2) | PI(16:0/18:2) | 7.57 ↑ | 8.81 ↓ | 7.11 ↓ | 7.70 ↓ |
| PI | PI(36:4) | PI(16:0/20:4) | 7.01 ↑ | 9.50 ↓ | 7.20 ↓ | 8.37 ↓ |
| PI | PI(38:5) | PI(18:1/20:4) | 8.02 ↑ | 9.39 ↓ | 6.88 ↓ | 7.67 ↓ |