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. 2023 Sep 26;13:16122. doi: 10.1038/s41598-023-43171-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Target validation. Out of the tested 17 targets, five genes (Fmr1: FMRP translational regulator 1/fragile X messenger ribonucleoprotein 1, Zfmp2: zinc finger protein, multitype 2, Wasl: WASP like actin nucleation promoting factor, Ets1: ETS proto-oncogene 1 and Atg16l1: autophagy related 16-like 1) showed reduced mRNA expression in the AB_HF (aortic banded group with systolic heart failure) compared to the AB_LVH (aortic banded group without systolic heart failure) group. Furthermore, a tendency towards decreased values without reaching the level of significance was observed in case of Phtf2 (putative homeodomain transcription factor 2), Nr3c1 (nuclear receptor subfamily 3, group C, member 1). Mier3 (MIER family member 3), Clock (clock circadian regulator) and Ankib3 (ankyrin repeat and IBR domain-containing protein 1). No changes could be detected in mRNA expression between the two study groups in case of Acsl4 (acyl-CoA synthetase long-chain family member 4), Tle4 (TLE family member 4, transcriptional corepressor), Wdfy3 (WD repeat and FYVE domain containing 3), Psd3 (pleckstrin And Sec7 Domain Containing 3), Jazf1 (JAZF zinc finger 1) and Epha5 (EPH receptor A5). Sample numbers were n = 8 in the AB_LVH and n = 5 in the AB_HF groups. Depending on the distribution of the datasets, two sample Student’s t test or Mann–Whitney tests were carried out. Data normalized to the AB_LVH are depicted. *P < 0.05.