Table 5.
Performance of liver stiffness (F-TE and ElastPQ), ElastPQ spleen stiffness and LSPS in predicting the presence of oesophageal varices in PSC.
| Test | OVs/n | Se (95% CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | PLR (95%CI) | NLR (95%CI) | Cut-off value (kPa) | AUROC (95% CI) | FN | FP | Tot misclassified |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F-TE LSM | 13/35 | 0.92 (0.64–1) | 0.62 (0.41–0.83) | 0.60 (0.46–0.73) | 0.93 (0.67–0.99) | 2.4 (1.4–4.5) | 0.13 (0.02–0.82) | 18.5 | 0.82 (0.68–0.96) | 1 | 8 | 9 |
| ElastPQ LSM | 13/35 | 0.92 (0.64–1) | 0.69 (0.45–0.86) | 0.63 (0.48–0.76) | 0.94 (0.69–0.99) | 3 (1.5–5.5) | 0.12 (0.02–0.76) | 21.1 | 0.83 (0.70–0.97) | 1 | 7 | 8 |
| ElastPQ SSM | 13/35 | 0.92 (0.64–1) | 0.77 (0.55–0.92) | 0.71 (0.52–0.84) | 0.94 (0.72–0.99) | 4 (1.9–8.9) | 0.10 (0.01–0.66) | 40.2 | 0.87 (0.76–0.99) | 1 | 5 | 6 |
| LSPS | 13/34 | 0.85 (0.55–0.98) | 0.67 (0.43–0.85) | 0.61 (0.45–0.75) | 0.86 (0.65–0.96) | 2.6 (1.3–4.9) | 0.22 (0.06–0.86) | 1.96 | 0.86 (0.74–0.98) | 2 | 7 | 9 |
ROC curve analysis and contingency table analysis used.
AUROC, area under receiver-operating characteristic; CI, confidence interval; FN, false negative; FP, false positive; F-TE, liver elastography performed with FibroScan; LSM, liver stiffness measurement; LSPS, liver stiffness x spleen diameter-to-platelet ratio score; n, number of patients with endoscopy; NLR, negative likelihood ratio; NPV negative predictive value; OVs, oesophageal varices; PLR, positive likelihood ratio; PPV, positive predictive value; PSC, primary sclerosing cholangitis; Se, sensitivity; Sp, specificity; SSM, spleen stiffness measurement.