Fig. 7.

Knockdown of SIRT1 reverses the effect of IB-exos on ER stress response. A. Immunofluorescence staining showing that knockdown of SIRT1 increased the expression levels of GRP78 and CHOP that were inhibited by IB-exos in LPS-treated HUVECs. Scale bar = 50 μm. B. Western blotting showing that knockdown of SIRT1 enhanced the phosphorylation of ERK that was reduced by IB-exos in LPS-treated HUVECs. Data was presented as means ± SD from three independent experiments. Statistical analysis was performed using one-way ANOVA. *P < 0.05, **P < 0.01.