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. 2023 Aug 10;16(5):847–856. doi: 10.1016/j.jcmgh.2023.08.003

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

GLP-2 treatment improves reactive cholangiocyte phenotype in Mdr2^-/-mice. (A) Representative Ck19 images (×10 magnification) show tendentially increased cholangiocyte proliferation in GLP-2-treated Mdr2^-/- animals, whereas representative osteopontin (Opn) images (×10 magnification) reflect reduced Opn secretion from cholangiocytes. Vcam-1 images (×10 magnification) remained unchanged among the groups. (B) Real-time polymerase chain reaction was used to assess the mRNA expression of Ck19, Opn, and Vcam-1. Whereas Ck19 expression tended to be increased, Opn levels were reduced and Vcam-1 remained unchanged in Mdr2^-/- mice treated with GLP-2. mRNA expression values were normalized against 36b4 levels and are shown relative to the expression level in Mdr2^-/- control animals. ∗Significant difference from Mdr2^-/- control mice; P < .05. Computational analysis of histologic pictures was done via Image J 1.51j8.