Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 10;16(5):847–856. doi: 10.1016/j.jcmgh.2023.08.003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

NR4a1/Nur77 mRNA expression is significantly increased in primary hepatic stellate cells because of GLP-2 treatment. (A) Real-time polymerase chain reaction was used to assess the mRNA expression of NR4a1/Nur77 in whole liver homogenate. mRNA expression values were normalized against 36b4 levels and are shown relative to expression level in Mdr2^-/- control subjects. ∗Significant difference from Mdr2^-/- control mice; P < .05 (B) Real-time polymerase chain reaction was used to assess the mRNA expression of NR4a1/Nur77 αSma and Col1a1 in primary hepatic stellate cells isolated from wild-type (WT) and Mdr2^-/- mice with and without GLP-2 treatment. GLP-2 treatment significantly increased expression levels of Nr4a1/Nur77. αSma and Col1a1 mRNA levels were significantly reduced in primary hepatic stellate cells isolated from Mdr2^-/- mice treated with GLP-2 compared with untreated Mdr2^-/- mice. mRNA expression values were normalized against 36b4 levels and are shown relative to the expression level in WT control animals. ^#Significant difference from Mdr2^-/- control mice; P < .05.