Table 2. Major AE profiles of ARSI and taxane.

Agent	Abiraterone	Enzalutamide	Apalutamide	Darolutamide	Docetaxel	Cabazitaxel
Major AEs	Fluid retention	Fall/Fracture	Fall/Fracture	Fatigue	Alopecia	Diarrhea
	Hepatic disorders	Fatigue	Fatigue		Change in taste	Fatigue
	Hypertension	Hot flashes	Hypothyroidism		Diarrhea	Infection
	Hypokalemia	Hypertension	Rash		Fatigue	Neutropenia
					Nail changes
					Neutropenia
					Peripheral edema
					Sensory neuropathy
					Stomatitis
Clinical trial	COU-AA-301 [5]	AFFIRM [7]	TITAN [21]	ARAMIS [28]	TAX 327 [3]	TROPIC [9]
	COU-AA-302 [6]	PREVAIL [8]	SPARTAN [26]		CHAARTED [19]	CARD [12]
	LATITUDE [20]	ENZAMET [22]
	STAMPEDE [38]	ARCHES [23]
		PROSPER [27]

AE: adverse event, ARSI: androgen receptor-signaling inhibitor.