#12	Search #9 AND #11
#11	Search randomized controlled trial OR randomized controlled trials OR controlled clinical trial OR controlled clinical trials OR random* OR trial OR trials OR groups OR double blind method OR double blind methods OR single blind method OR single blind methods OR clinical trial OR clinical trials OR research design OR controlled study OR controlled studies OR "clinical study" OR "clinical studies" OR control OR controlled OR controls
#10	Search #8 AND (animals[mh] NOT humans[mh])
#9	Search #8 NOT (animals[mh] NOT humans[mh])
#8	Search #7 NOT (editorial[pt] OR letter[pt] OR case reports[pt] OR news[pt] OR newspaper article[pt])
#7	Search #3 OR #5 OR #6
#6	Search #4 AND (neoplasm*[ti] OR tumor*[ti] OR tumour*[ti] OR cancer*[ti]) AND (recur*[ti] OR risk*[ti] OR metasta*[ti])
#5	Search #2 AND #4 AND neoplasm[mh] AND adverse effects[sh]
#4	Search opioid* OR opiate* OR morphine* OR alfentanil OR alphadolone OR alphaxalone OR benoxinate OR benzocaine OR "benzyl alcohol" OR bumecain OR bupivacaine OR butamben OR carbizocaine OR carticaine OR chloralose OR chloroprocaine OR cyclopropane OR desflurane OR diazepam OR dibucaine OR diphenhydramine OR dyclonine OR emla OR enflurane OR entonox OR etidocaine OR etomidate OR ether OR fentanyl OR halothane OR heptacaine OR innovar OR isoflurane OR ketamine OR levobupivacaine OR lidocaine OR lignocaine OR "magnesium sulfate" OR mepivacaine OR methohexital OR methoxyflurane OR methyleugenol OR midazolam OR minaxolone OR "nitrous oxide" OR norflurane OR pentacaine OR phenoxyethanol OR pregnanolone OR prilocaine OR procaine OR propanidid OR propisomide OR propofol OR propoxycaine OR proxymetacaine OR remifentanil OR romifidine OR ropivacaine OR sevoflurane OR "sodium oxybate" OR sufentanil OR "tec solution" OR tetracaine OR tetrahydrodeoxycorticosterone OR tetrodotoxin OR thiamylal OR thiopental OR tiletamine OR tribromoethanol OR tricaine OR trichloroethylene OR trimecaine OR urethane OR anesthe*[ti] OR anaesthe*[ti] OR analges*[ti]
#3	Search #1 AND #2
#2	Search neoplasm recurrence, local[mh] OR neoplasm invasiveness[mh] OR neoplasm metastasis[mh] OR cocarcinogenesis[mh]
#1	Search "anesthesia and analgesia"[mh:noexp] OR anesthesia[mh] OR analgesia[mh:noexp] OR analgesia, epidural[mh] OR analgesia, patient‐controlled[mh] OR anesthetics[majr] OR anesthetics/adverse effects OR anesthetics/immunology OR anesthetics/pharmacology OR analgesics[majr] OR analgesics/adverse effects OR analgesics/immunology OR analgesics/pharmacology OR adjuvants, anesthesia[mh]