Figure 6: Faster initiation of cell proliferation in HNF4α-cMyc DKO mice after APAP overdose.
(A) Western blot analysis of PCNA and CyclinD1 performed using pooled (n=3-5) liver lysates from WT and DKO mice at various time points.(B) Densitometric analysis of PCNA and CyclinD1 Western blots. (C) Ki67 immunohistochemistry of WT and DKO mice at 0, 6, 24, 48 h after APAP overdose. Red arrows pointing to Ki67 positive cells. Original magnification, 400X