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. Author manuscript; available in PMC: 2023 Sep 27.
Published in final edited form as: Toxicol Appl Pharmacol. 2020 May 15;399:115040. doi: 10.1016/j.taap.2020.115040

Fig. 1. The circadian clock protects against acute radiodermatitis.

Fig. 1.

SKH-1 hairless female mice (8- to 12-week old) were used in all groups. Day Shift (D.S.) serves as control, while Rotating Shift (R.S.) and Per1/2−/− represent the environmentally- and genetically-disrupted clock conditions. a) The study design showing wild-type mice placed in Rotating Shift, characterized by weekly alternating Light/Dark cycles, for 15 days prior to IR treatment and through the duration of the study. Mice received a 6 Gy single dose of total body IR on Day 0. b) Dermatitis (red) spots (circled white) on mice skin were carefully observed and counted across the body post-IR c) Dot plot showing the number of dermatitis spots per mouse counted on Day 13 post-IR. Statistical comparison was done using Student’s t test *=p<0.05. **=p<0.01. Error bars = S.E.M. (n=5–6 mice per group).