| In hospital | After discharge (years) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Before birth until 60 min | < 60 min | 72–84 h | 36 weeks p.m | Discharge | 1 | 2 | 3 | 4 | 5 | |
| Eligibility screen | x | |||||||||
| Informed consent | x | |||||||||
| Allocation | x | |||||||||
| Intervention group: prophylactic surfactant immediately after allocation | x | |||||||||
| Control group: no prophylactic surfactant after allocation | x | |||||||||
| Baseline assessment | x | |||||||||
| Outcome assessment (safety) | x | x | x | x | x | x | x | x | ||
| Adverse events | x | x | x | |||||||
| Outcome assessment (efficacy) | x | |||||||||
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