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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2023 Apr 11;14(5):e1788. doi: 10.1002/wrna.1788

Figure 1. An overview of the HNRNPF/H proteins.

Figure 1.

(A) Schematics of the HNRNPF/H protein family. The indicated domains are based on the UniProt reference human proteins as follows: HNRNPF - P52597, HNRNPH1 – P31943, HNRNPH2 – P55795, HNRNPH3 – P31942, GRSF1 – Q12849. (B) The amino acid sequence alignment of the reference HNRNPF/H proteins were generated using R-packages msa (Bodenhofer et al., 2015) and ggmsa (Zhou et al., 2022). The indicated qRRMs, related structural elements (β-sheet, α-helix, turns), and low complexity domains are based on those reported for HNRNPF (P52597), except for the C-terminus of HNRNPH3 (P31942) and the additional GRSF1 domains (Q12849). The amino acids in red indicate residues that contact RNA, and those in blue, indicate residues that form a putative nuclear localization signal. Figure panels created with BioRender.com.