Table 4 –
Relative rates of major depression or suicide death among men diagnosed with high-risk PC (1998–2017) in comparison to matched control subjects, stratified by age at the index date
| Age at index date | Men with the outcome (n) | Adjusted modela | ||
|---|---|---|---|---|
| PC cases | Controls | HR (95% CI) | p value | |
| Major depression | ||||
| <55 yr | 148 | 1162 | 1.54 (1.25–1.88) | <0.001 |
| 55–64 yr | 968 | 8301 | 1.58 (1.45–1.73) | <0.001 |
| 65–74 yr | 2226 | 23 455 | 1.73 (1.62–1.84) | <0.001 |
| 75–84 yr | 2533 | 28 635 | 1.98 (1.86–2.10) | <0.001 |
| ≥85 yr | 615 | 6678 | 2.21 (1.94–2.52) | <0.001 |
| Suicide death | ||||
| <55 yr | 5 | 19 | 2.23 (0.73–6.83) | 0.16 |
| 55–64 yr | 23 | 186 | 1.42 (0.88–2.31) | 0.15 |
| 65–74 yr | 62 | 327 | 2.79 (1.97–3.94) | <0.001 |
| 75–84 yr | 74 | 319 | 2.68 (1.96–3.68) | <0.001 |
| ≥85 yr | 20 | 66 | 4.36 (2.06–9.22) | <0.001 |
CI = confidence interval; HR = hazard ratio; PC = prostate cancer.
a
Adjusted for age, country of birth, marital status, education, income, region, Charlson comorbidity index, and prior history of psychiatric disorders (bipolar disorder, schizophrenia, anxiety disorder, major depression) at the index date.