Table 2.

Adjusted odds of oral anticoagulant initiation by thromboembolic risk, bleeding risk, frailty, and reason for hospitalization

	Initiated anticoagulation within 7 days		Initiated anticoagulation within 30 days
	N (%)	Odds ratio (95% CI)	N (%)	Odds ratio (95% CI)
Thromboembolic Risk a
Low	401/1,746 (22.0%)	Reference	525/1,746 (30.1%)	Reference
Moderate	1,386/5,170 (26.8%)	1.24 (1.08,1.42)	1,795/5,170 (34.7%)	1.29 (1.13,1.47)
High	7,625/31,463 (24.2%)	1.33 (1.16,1.51)	9,555/31,463 (30.4%)	1.35 (1.19,1.52)
Bleeding Risk b
Low	1,959/7,084 (27.7%)	Reference	2,491/7,084 (35.2%)	Reference
Moderate	3,856/14,106 (27.3%)	1.02 (0.95,1.09)	4,854/14,106 (34.4%)	1.02 (0.95,1.09)
High	3,597/17,189 (20.9%)	0.87 (0.81,0.94)	4,530/17,189 (26.4%)	0.87 (0.81,0.93)
Frailty Category
Not frail	903/2,944 (30.7%)	Reference	1,190/2,9944 (40.4%)	Reference
Prefrail	6,024/21,294 (28.3%)	1.08 (0.98,1.18)	7,590/21,294 (35.6%)	0.999 (0.91,1.09)
Mildly frail	2,076/10,729 (19.3%)	0.89 (0.80,0.996)	2,576/10,729 (24.0%)	0.79 (0.72,0.88)
Moderately-severely frail	409/3,412 (12.0%)	0.64 (0.56,0.75)	519/3,412 (15.2%)	0.59 (0.51,0.67)
Primary Reason for Hospitalization
Atrial fibrillation	3,773/7,845 (48.1%)	Reference	4,796/7,845 (61.1%)	Reference
Bleeding	33/935 (3.5%)	0.04 (0.03,0.06)	50/935 (5.3%)	0.04 (0.03,0.05)
Cardiac surgery	474/1,043 (45.4%)	0.85 (0.74,0.97)	521/1,043 (50.0%)	0.59 (0.52,0.67)
Other cardiovascular	2,809/11,001 (25.5%)	0.39 (0.37,0.42)	3,506/11,001 (31.9%)	0.32 (0.30,0.34)
Other non-cardiovascular	2,323/17,555 (13.2%)	0.18 (0.17,0.19)	3,002/17,555 (17.1%)	0.15 (0.14,0.16)

^aFor thromboembolic risk, CHA₂DS₂-VASc score <2 was considered low, 2–3 moderate, and ≥4 high.

^bFor bleeding risk, HAS-BLED score <2 was considered low, 2 moderate and ≥3 high.